结构生物学

 本课题组以X射线晶体学/单颗粒冷冻电镜等结构生物学手段为基础，结合生物化学和细胞生物学等方法，开展与人类疾病密切相关的蛋白质机器的结构和功能研究，特别是定位于细胞器膜上的离子通道/离子转运蛋白等，并基于这些靶标开展相关疾病的药物筛选。

欢迎本科生，博士后加入我们的团队，共同探索未知的领域。且欢迎广大科研爱好者来实验室交流，学习，访问，合作。

1． Chen, Q., Zeng, W., She, J., Bai, X. C., and Jiang, Y. (2019) Structural and functional characterization of an otopetrin family proton channel. Elife 8, e46710.

2． She, J., Zeng, W., Guo, J., Chen, Q., Bai, X. C., and Jiang, Y. (2019) Structural mechanisms of phospholipid activation of the human TPC2 channel. Elife 8, e45222.

3． She, J.*, Guo, J.*, Chen, Q.*, Zeng, W., Jiang, Y., and Bai, X. C. (2018) Structural insights into the voltage and phospholipid activation of mammalian TPC1 channel. Nature 556, 130–134. (*equal contribution)

4． Guo, J.*, She, J.*, Zeng, W., Chen, Q., Bai, X. C., and Jiang, Y. (2017) Structures of the Calcium-activated Non-Selective Cation Channel TRPM4, Nature 552, 205–209. (*equal contribution. Highlighted in "Editors' Choice” in Science Signaling)

5． Chen, Q.*, She, J.*, Zeng, W., Guo, J., Xu, H., Bai, X. C., and Jiang, Y. (2017) Structure of mammalian endolysosomal TRPML1 channel in nanodiscs, Nature 550, 415-418. (*equal contribution. Highlighted in "Editors' Choice” in Science Signaling)

6． Guo, J., Zeng, W., Chen, Q., Lee, C., Chen, L., Yang, Y., Cang, C., Ren, D., Jiang, Y. (2016) Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana. Nature 531, 196-201.

7． Chen, Q.*, Chen, X.*, Wang, Q., Zhang, F., Lou, Z., Zhang, Q., Zhou, D. (2013) Structural basis of a histone H3 lysine 4 demethylase required for stem elongation in rice. PLoS Genet 9, e1003239. (*equal contribution)

8． Chen, Q., Wang, Q., Xiong, L., and Lou, Z. (2011). A structural view of the conserved domain of rice stress-responsive NAC1. Protein & Cell 2, 55-63.

9． Westfall, C.S., Herrmann, J., Chen, Q., Wang, S., and Jez, J.M. (2010). Modulating plant hormones by enzyme action: the GH3 family of acyl acid amido synthetases. Plant Signal Behav 5, 1607-1612.

10． Chen, Q., Westfall, C.S., Hicks, L.M., Wang, S., and Jez, J.M. (2010). Kinetic basis for the conjugation of auxin by a GH3 family indole-acetic acid-amido synthetase. J Biol C...

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Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming 650091, China.

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